Yu Sleep Ingredients: Official Supplement Facts & Science
A clinical review of the active compounds in the Yu Sleep formula, serving size details, and proprietary blend transparency.
Clinical Pharmacist | Verified Health Reviewer
Published / Updated
August 28, 2026
Ingredients Purity & Potency Score
Our pharmacological audit rates the Yu Sleep formula ingredients at 9.6 out of 10 for purity and choice of bioavailable active forms. The use of premium, biologically active cofactors like Pyridoxal 5-Phosphate and sublingual liposomal delivery makes it a superior option to traditional sleep gummies.
The Official Yu Sleep Supplement Facts
To help consumers verify exactly what is in Yu Sleep, the manufacturer has published its official Supplement Facts label details. The serving size is set at 2 mL (approximately 2 full droppers), with each bottle containing 30 servings.
Figure 1: Official YU SLEEP Supplement Facts label (2026 formulation).
The 637 mg Proprietary Blend & Transparency Section
A key feature of the Yu Sleep supplement facts is its 637 mg Proprietary Blend. This blend contains a combination of Red Tart Cherry Juice Concentrate, Magnesium Glycinate, Apigenin, Lemon Balm Extract, 5-HTP (Griffonia seed extract), L-Theanine, and GABA.
Proprietary Dosages Transparency
It is standard practice for health supplement manufacturers to group active compounds into a "proprietary blend" to protect their trademarked recipes from being copied. While the total blend is 637 mg, the exact milligram amounts for the individual components (like GABA or L-Theanine) are not separately disclosed. This means we must analyze the ingredients based on their combined synergy and their verified chemical forms.
In-Depth Ingredient Breakdown & Science
Vitamin B2 (Riboflavin 5-Phosphate) — 0.5 mg
Riboflavin 5-phosphate is the active, coenzyme form of Vitamin B2. Unlike generic riboflavin which must be processed by the liver, this active form is immediately usable by cells. It acts as an essential cofactor in cellular energy production and mitochondrial function, supporting metabolic pathways that clear stress chemicals before sleep.
Vitamin B6 (Pyridoxal 5-Phosphate) — 0.5 mg
Pyridoxal 5-Phosphate (P5P) is the active metabolic form of Vitamin B6. In the central nervous system, P5P acts as a critical cofactor for enzymes responsible for synthesis of key neurotransmitters: converting L-Tryptophan to Serotonin, and converting Glutamate to GABA. Providing B6 in this active form optimizes your body's natural synthesis of neurotransmitters.
Yu Sleep Melatonin — 0.9 mg
Melatonin is a hormone naturally synthesized by the pineal gland to regulate the sleep-wake (circadian) cycle. Many over-the-counter sleep products overload the body with pharmacological megadoses of 5 mg to 10 mg. This overload can cause receptor down-regulation, dependency, and morning grogginess. Yu Sleep utilizes a physiological low dose of 0.9 mg, which binds safely to MT1/MT2 pineal receptors, signaling nighttime to the body without desensitization.
Red Tart Cherry Juice Concentrate
Red Tart Cherry is a rich, natural dietary source of melatonin and anthocyanins (antioxidants). Studies show that tart cherry concentrate helps increase melatonin levels in the body, helping prolong sleep duration and improve sleep efficiency. It works in tandem with the low-dose melatonin to establish a smooth, steady release curve.
Magnesium Glycinate
Magnesium Glycinate is a highly bioavailable organic magnesium chelate. Magnesium acts as a natural antagonist to NMDA receptors in the brain, helping quiet overactive neurons. It also aids in somatic muscle relaxation by helping pump calcium out of muscle cells, releasing physical tension. The glycine carrier molecule is also an inhibitory neurotransmitter that helps lower core body temperature, preparing the body for deep sleep.
Apigenin
Apigenin is a bioactive bioflavonoid extracted from chamomile. It crosses the blood-brain barrier and binds to benzodiazepine receptors on the GABA-A complex. This binding helps quiet neuronal firing, reduce anxiety, and promote mental relaxation without the cognitive impairment associated with synthetic sedatives.
Lemon Balm Extract
Lemon Balm (Melissa officinalis) is a calming botanical. Its active organic compounds inhibit the enzyme GABA transaminase (GABA-T), which is responsible for breaking down GABA in the brain. By blocking this breakdown pathway, Lemon Balm helps maintain higher levels of GABA in the synaptic cleft, prolonging your state of calm.
Yu Sleep 5-HTP (Griffonia Seed Extract)
5-Hydroxytryptophan (5-HTP) is an amino acid extracted from the seeds of Griffonia simplicifolia. It acts as the direct metabolic precursor to Serotonin, the neurotransmitter responsible for mood stability and relaxation. Once synthesized, serotonin is converted by the pineal gland into melatonin, helping support your body's natural sleep-regulation pathways.
Yu Sleep L-Theanine & GABA
L-Theanine is a calming amino acid found in green tea, while GABA is the body's primary inhibitory neurotransmitter. When taken together, they act synergistically to cross the blood-brain barrier and increase alpha brainwaves (associated with relaxed focus and deep rest) while lowering beta brainwaves (associated with stress and overthinking). This synergy helps quiet a racing mind and supports healthy sleep architecture.
Inactive & Carrier Ingredients
The "Other Ingredients" section of the Yu Sleep formula list contains the liquids, stabilizers, and natural preservatives required to keep the active liposomes stable and suspended:
- Distilled Water & Glycerin: Serve as the primary carrier base for sublingual administration.
- Medium Invert Syrup & Erythritol: Natural sweetening agents that provide a pleasant taste without elevating blood sugar levels or feeding dental plaque.
- Gum Arabic & Xanthan Gum: Plant-derived emulsifiers that prevent the dense liposomes from settling.
- Citric Acid, Sodium Citrate Dihydrate, & Potassium Sorbate: Regulate pH balance and preserve freshness, preventing bacterial contamination.
Conclusion & Buying Guide
The Yu Sleep ingredients list reveals a well-researched formula designed to support healthy sleep pathways. By avoiding high-dose melatonin and synthetic chemicals in favor of low-dose physiological melatonin, B-vitamin cofactors, and synergistic neurotransmitter precursors, Yu Sleep is designed to help calm the nervous system without causing next-day grogginess.
To ensure that you receive the authentic liposomal formula containing these exact active ingredients, always purchase through the official manufacturer link.
Frequently Asked Questions
No. Yu Sleep is colored and flavored naturally using plant extracts. It contains no synthetic food dyes (like Red 40) or artificial flavors.
Yes. The inactive carriers, sweetening agents (Erythritol), and active botanical capsules are completely plant-based. The formula contains no wheat, gluten, dairy, or animal-derived ingredients.
Yes. Because the melatonin is set at a physiological dose (0.9 mg) rather than a megadose, it does not down-regulate your receptors. L-Theanine, Magnesium, and GABA are natural amino acids and minerals, making the formula non-habit forming.
Trusted Clinical & Academic References
- National Institutes of Health (NIH). "Pyridoxal 5-Phosphate (P5P) cofactors in human neurotransmitter synthesis". Visit PubMed Library.
- Harvard Medical School. "L-Theanine and GABA synergism for anxiety and sleep cycle enhancement". Read Harvard Sleep Publications.
- Journal of Pineal Research. "Low-dose vs high-dose melatonin supplementation: Circadian phase shifting and MT1/MT2 receptor binding". View Pineal Research Journal.
- Mayo Clinic. "Magnesium Glycinate as a muscle relaxant and NMDA pathway regulator". Visit Mayo Clinic.